Multi-center and Multi-omics Mechanism Research of Gut Microbiota and Metabonomics in Borrmann Type IV Gastric Cancer
Status: Recruiting
Location: See all (6) locations...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
To evaluate the correlation between gut microbiota and metabolites in Borrmann type IV gastric cancer; To find the effects of microflora and metabolites on target organs; To detect the mechanism of key flora and metabolite by in vitro and in vivo experiments; To construct models of gut microbiota and metabonomics by machine learning.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:
• Patients who sign informed consent.
• Borrmann classification of gastric cancer is determined by more than 2 pathologists.
• Patients with BMI 24-28.
• Karnofsky (KPS) score \>80.
Locations
Other Locations
China
The fourth People's Hospital of Changzhou
RECRUITING
Changzhou
Chaoyang Central Hospital
RECRUITING
Chaoyang
The General Hospital of Fushun Mining Bureau
ENROLLING_BY_INVITATION
Fushun
The Second Hospital of Shandong University
ENROLLING_BY_INVITATION
Ji'nan
First Hospital of Jinzhou Medical University
RECRUITING
Jinzhou
The First Affiliated Hospital of China Medical University
ACTIVE_NOT_RECRUITING
Shenyang
Contact Information
Primary
Kai Li, MD
cmu1h_likai@163.com
8613998245233
Time Frame
Start Date: 2022-02-28
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 450
Treatments
Healthy group
Healthy people in the community.
Non-Borrmann IV group
Patients with Borrmann types I, II and III gastric cancer.
Borrmann IV group
Patients with Borrmann type IV gastric cancer.
Related Therapeutic Areas
Sponsors
Collaborators: Liaoning Cancer Hospital & Institute, The Second Hospital of Shandong University, The General Hospital of Fushun Mining Bureau, The fourth People's Hospital of Changzhou, The First People's Hospital of Jingzhou
Leads: First Hospital of China Medical University